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Nowadays, depression is a fairly common condition. Depression often develops slowly and imperceptibly for the person and for his family. Initially, most people are unaware of their illness, attributing many of the symptoms of depression to the characteristics of his personality. Address to the doctor usually takes place at a time when the disease is already firmly holding the patient. Risk factors for depression are being female, the presence of depression in family history, early history of depression, early loss of parents, experienced the experience of violence in history, personality traits, stressors (separation, guilt), alcohol / drug dependency, neurological diseases (Parkinson's disease, apoplexy). Depression affects all aspects of human life. Inadequate psychological defense mechanisms, in turn, have a destructive impact not only on psychological and biological processes. The first signs of depression are apathy, independent of circumstances, apathy to everything going on, weakening of physical activity - the main clinical symptoms of depression. If there is a combination of more than two weeks - need urgent professional help for depression.

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The modern approach to depression symptoms treatment generally involves a combination of different methods:

  • biological treatment (medication);
  • psychotherapy.

Medication is assigned in patients with mild, moderate and severe symptoms of depression. Depression help requires treatment by specialists. Antidepressants may help alleviate anxiety symptoms and depression. In connection with the calming effect of certain antidepressants, they can take a lot of people with panic disorder and anxiety. In many cases, these preparations need to be taken are two times a day. You perhaps need to take them for a few weeks before the condition begins to improve. Do not change the dose (take no less and no more) or and do not stop taking medication without consulting your doctor. Many antidepressants need to take a long time - up to 8 months. It is very important at the beginning of treatment to bring it to the end (even if you feel better before the expiration of the treatment). Your doctor will help you choose the most appropriate medication for you, and the dose. For best results of treatment, it is important you carefully follow all instructions of your doctor. New antidepressants which help with depression are fluoxetine (Prozac), sertraline (Zoloft), citalopram (Celexa), paroxetine (Paxil), fluvoxamine (Luvox), mirtazapine (Remeron), and many others. Antidepressants are safe class of psychotropic products, if properly applied according to doctor's recommendation.

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The main side effects of antidepressants include anti-cholinergic disorders of the central and autonomic nervous system, the cardiovascular system, complications of the hematopoiesis, metabolic and endocrine disorders (changes in body weight, sexual dysfunction sphere, allergic reactions). Adverse reactions most often appear in the early stages of treatment and sometimes stored for 3-4 weeks of therapy, and then subjected to reverse development. A more persistent and, at the same time expressed violations are shown to reduce the dose, and if necessary - cessation of therapy.

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Pharmacodynamic interaction is mainly due to the action of various types of central and peripheral receptors. It is necessary to be particularly careful with a combination of tricyclic antidepressants with other drugs. Tricyclic antidepressants may potentiate the effects of opioid analgesics, antiarrhythmics and anticoagulants. The combined use of them with antihistamines and antiparkinsonian medications can cause pronounced sedation and strengthen the anticholinergic side effects. With the combination of MAO inhibitors, tricyclic antidepressants patients may experience severe autonomic dysfunction, a sharp increase in blood pressure, convulsions, hyperpyrexia.

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